| Date | Location | Result | |
| 03/04/22 | Shawnee, OK | Southern Nazarene 69, Henderson State 58 | Box score |
| 02/26/22 | Arkadelphia, AR | Henderson State 90, Harding 72 | Box score |
| 02/25/22 | Russellville, AR | Arkansas Tech 79, Henderson State 65 | Box score |
| 02/19/22 | Ada, OK | Henderson State 90, East Central 71 | Box score |
| 02/17/22 | Durant, OK | Southeastern Okla. 85, Henderson State 80 | Box score |
| 02/14/22 | Arkadelphia, AR | Henderson State 70, East Central 69 (OT) | Box score |
| 02/12/22 | Arkadelphia, AR | Henderson State 72, Northwestern Okla. 69 | Box score |
| 02/10/22 | Arkadelphia, AR | Southwestern Okla. 71, Henderson State 60 | Box score |
| 02/07/22 | Arkadelphia, AR | Henderson State 57, Ouachita Baptist 49 | Box score |
| 02/05/22 | Arkadelphia, AR | Henderson State 77, Southern Ark. 68 | Box score |
| 01/29/22 | Shawnee, OK | Okla. Baptist 90, Henderson State 81 | Box score |
| 01/27/22 | Bethany, OK | Southern Nazarene 67, Henderson State 61 | Box score |
| 01/24/22 | Arkadelphia, AR | Southern Nazarene 56, Henderson State 50 | Box score |
| 01/22/22 | Arkadelphia, AR | Henderson State 84, Southeastern Okla. 73 | Box score |
| 01/15/22 | Monticello, AR | Henderson State 48, Ark.-Monticello 45 | Box score |
| 01/13/22 | Arkadelphia, AR | Henderson State 59, Ouachita Baptist 56 | Box score |
| 01/08/22 | Weatherford, OK | Henderson State 80, Southwestern Okla. 70 | Box score |
| 01/06/22 | Alva, OK | Northwestern Okla. 76, Henderson State 66 | Box score |
| 12/30/21 | Arkadelphia, AR | Okla. Baptist 83, Henderson State 78 | Box score |
| 12/20/21 | Dallas, TX | Henderson State 78, DBU 75 | Box score |
| 12/18/21 | Searcy, AR | Henderson State 71, Harding 49 | Box score |
| 12/11/21 | Arkadelphia, AR | Arkansas Tech 84, Henderson State 78 (OT) | Box score |
| 12/04/21 | Magnolia, AR | Henderson State 65, Southern Ark. 62 | Box score |
| 12/02/21 | Arkadelphia, AR | Henderson State 54, Ark.-Monticello 50 | Box score |
| 11/24/21 | Arkadelphia, AR | Henderson State 59, Pittsburg St. 57 | Box score |
| 11/20/21 | Fort Smith, AR | Ark.-Fort Smith 81, Henderson State 80 (OT) | Box score |
| 11/17/21 | Arkadelphia, AR | Henderson State 79, Texas Col. 60 | Box score |
| 11/14/21 | Kansas City, Mo. -- Municipal Auditorium | Henderson State 81, Missouri Western 77 (OT) | Box score |
| 11/13/21 | Kansas City, Mo. -- Municipal Auditorium | Winona St. 79, Henderson State 62 | Box score |