| Date | Location | Result | |
| 03/05/22 | Shawnee, OK | Southwestern Okla. 89, Henderson State 73 | Box score |
| 03/04/22 | Shawnee, OK | Henderson State 79, East Central 66 | Box score |
| 02/26/22 | Arkadelphia, AR | Henderson State 95, Harding 85 | Box score |
| 02/25/22 | Russellville, AR | Henderson State 85, Arkansas Tech 57 | Box score |
| 02/19/22 | Ada, OK | Henderson State 63, East Central 57 | Box score |
| 02/17/22 | Durant, OK | Henderson State 57, Southeastern Okla. 49 | Box score |
| 02/12/22 | Arkadelphia, AR | Henderson State 87, Northwestern Okla. 78 | Box score |
| 02/10/22 | Arkadelphia, AR | Southwestern Okla. 90, Henderson State 78 | Box score |
| 02/07/22 | Arkadelphia, AR | Ouachita Baptist 73, Henderson State 71 | Box score |
| 02/05/22 | Arkadelphia, AR | Henderson State 96, Southern Ark. 72 | Box score |
| 01/29/22 | Shawnee, OK | Okla. Baptist 79, Henderson State 68 | Box score |
| 01/27/22 | Bethany, OK | Southern Nazarene 63, Henderson State 41 | Box score |
| 01/24/22 | Arkadelphia, AR | Southern Nazarene 66, Henderson State 62 | Box score |
| 01/22/22 | Arkadelphia, AR | Henderson State 76, Southeastern Okla. 57 | Box score |
| 01/20/22 | Arkadelphia, AR | East Central 76, Henderson State 71 | Box score |
| 01/15/22 | Monticello, AR | Henderson State 68, Ark.-Monticello 58 | Box score |
| 01/13/22 | Arkadelphia, AR | Henderson State 91, Ouachita Baptist 89 | Box score |
| 01/08/22 | Weatherford, OK | Southwestern Okla. 99, Henderson State 78 | Box score |
| 01/06/22 | Alva, OK | Northwestern Okla. 84, Henderson State 78 | Box score |
| 12/30/21 | Arkadelphia, AR | Henderson State 94, Okla. Baptist 80 (OT) | Box score |
| 12/18/21 | Searcy, AR | Henderson State 82, Harding 78 | Box score |
| 12/15/21 | Arkadelphia, AR | Henderson State 112, Bacone 49 | Box score |
| 12/11/21 | Arkadelphia, AR | Henderson State 77, Arkansas Tech 72 | Box score |
| 12/04/21 | Magnolia, AR | Southern Ark. 112, Henderson State 99 | Box score |
| 12/02/21 | Arkadelphia, AR | Henderson State 75, Ark.-Monticello 39 | Box score |
| 11/24/21 | Fort Smith, AR | Henderson State 91, Ark.-Fort Smith 61 | Box score |
| 11/20/21 | Tyler, TX | Henderson State 73, Texas-Tyler 65 | Box score |
| 11/17/21 | Arkadelphia, AR | Henderson State 86, Christian Brothers 45 | Box score |
| 11/13/21 | Emporia St. 84, Henderson State 66 | Box score | |
| 11/12/21 | Joplin, MO | Henderson State 81, Mo. Southern St. 74 | Box score |